SELF-STABILIZED OLIGONUCLEOTIDES AS THERAPEUTIC AGENTS

摘要

2139319 9401550 PCTABS00030 The invention provides improved antisense oligonucleotides that are resistant to nucleolytic degradation. Such oligonuclotides are called self-stabilized oligonucleotides and comprise two regions: a target hybridizing region having a nucleotide sequence complementary to a nucleic acid sequence that is from a virus, a pathogenic organism, or a cellular gene; and a self-complementary region having an oligonucleotide sequence complementary to a nucleic acid sequence that is within the self-stabilized oligonucleotide.