2-formylbenzylphosphonic acid derivatives useful for the treatment of diseases caused by viruses

摘要

The compound of the formula I <IMAGE> I in which R is an aldehyde group or a group which can be converted into an aldehyde, R1 and R2 are alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, hydrogen, sodium, potassium, calcium, magnesium, aluminum, lithium, ammonium or triethylamnonium, or R1 and R2 together form a cyclic diester, R3 and R4 are alkyl, alkenyl, alkynyl, cycloalkyl, hydrogen, alkoxy or halogen, R5 and R8 are alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, alkoxy, phenyl, cyanide, hydroxyl or hydrogen, and X, Y or Z are oxygen or sulfur, or prodrug forms of the compound of the formula I can be used for the treatment of diseases caused by viruses. The preparation of these compounds and pharmaceutical preparations containing them and their use is described.