Bivalente Lebendvakazine gegen bakterielle Darmpathogene, Herstellungsverfahren sowie Plasmide und Stämme als Ausgangsmaterial
摘要
A bivalent S. typhi living vaccine is disclosed. The micro-organism contained in this vaccine is capable of expressing a complete LPS with a S.-typhi core and heterologous O-polysaccharides. The micro-organism can be produced by transferring the rfa-L gene from E. coli and the gene region of a cross-reacting species whose genetic products catalyze the biosynthesis of O-lipopolysaccharides, into S. typhi.
申请公布号
DE4221840(A1)
申请公布日期
1994.01.05
申请号
DE19924221840
申请日期
1992.07.03
申请人
GESELLSCHAFT FUER BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF), 38124 BRAUNSCHWEIG, DE