发明名称 |
Haptens useful in evaluating inhibition of PMN elastase by N-substituted azetidinones |
摘要 |
N-substituted azetidinones are a class of inhibitors of human leukocytes elastase which are known to be useful in the treatment of a wide variety of antiinflammatory and antidegenerative diseases. In inhibiting elastase, the therapeutic agents are shown to form a characteristic stable complex with the enzyme. In the radioimmune assay disclosed herein, the inhibitor-enzyme complex is advantageously hydrolyzed and specific product(s) of the hydrolysis are measured. The assays are useful in a clinical setting, for determining appropriate dosage and assessing the effectiveness of treatment.
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申请公布号 |
US5276139(A) |
申请公布日期 |
1994.01.04 |
申请号 |
US19910750148 |
申请日期 |
1991.08.26 |
申请人 |
MERCK & CO., INC. |
发明人 |
FINKE, PAUL E.;HAGMANN, WILLIAM K.;MUMFORD, RICHARD A.;SHAH, SHRENIK K. |
分类号 |
C07C275/28;C07C275/40;C07D307/79;C07K16/44;C12Q1/37;G01N33/94;(IPC1-7):C07K3/08;C07C275/04;G01N33/68 |
主分类号 |
C07C275/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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