ARYL THIOPYRANO[4,3,2-CD]INDOLES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS

摘要

269/GL115 18735 TITLE OF THE INVENTION ARYL THIOPYRANO¢4,3,2-cd!INDOLES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS Compounds having the formula I: <IMG> I are inhibitors of the 5-lipoxygenase enzyme and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, antiallergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, psoriasis, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.