| 发明名称 |
MODIFIED RIBOZYMES |
| 摘要 |
<p>The present invention refers to an RNA molecule with catalytic activity comprising at least one modified nucleoside, wherein the hydroxy group at the 2'-position of the fibose sugar is replaced by a modifier group, selected from halo, sulfhydryl, azido, amino, monosubstituted amino, and disubstituted andno groups, a process for the preparation of modified KNA molecules and the use of modified KNA molecules as therapeutic agents and biocatalysts.</p> |
| 申请公布号 |
GR930300130(T1) |
申请公布日期 |
1993.12.30 |
| 申请号 |
GR19930300130T |
申请日期 |
1993.12.30 |
| 申请人 |
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. |
发明人 |
ECKSTEIN, FRITZ;PIEKEN, WOLFGANG, A.;BENSELER, FRITZ;OLSEN, DAVID;WILLIAMS, DAVID, M.;HEIDENREICH, OLAF |
| 分类号 |
A61K31/70;A61K31/00;A61K31/712;A61K38/00;A61K48/00;A61P31/18;C07H21/02;C12N9/00;C12N15/00;C12N15/09;C12N15/113;(IPC1-7):C12N9/00 |
主分类号 |
A61K31/70 |
| 代理机构 |
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