NON-FIBROGENIC, ALGINATE-COATED TRANSPLANTS, PROCESS OF MANUFACTURE AND METHOD OF USE THEREOF

摘要

A tissue transplant comprises viable, physiologically active, tissue cells and has a non-fibrogenic coating of a divalent metal alginate. The coating has a sufficiently low permeability and a sufficiently large thickness to protect the tissue cells from host immunological agents after transplantation, and is sufficiently permeable and thin to permit the diffusion of sufficient cell nutrients and cell products through the coating required for cell viability. The tissue cells may be pancreatic islet cells, neural cells, renal cortex cells, vascular endothelial cells, thyroid cells, adrenal cells, thymic cells, ovarian cells, hepatic cells, and the like.