发明名称 |
Dioxo-tetrahydroquinoline derivatives |
摘要 |
A class of 2,4-dioxo-1,2,3,4-tetrahydroquinoline derivatives, substituted at the 3-position by a range of carbonyl-containing substituents or by a five- or six-membered heteroaromatic moiety, are selective non-competitive antagonists of NMDA receptors and/or are antagonists of AMPA receptors, and are therefore of utility in the treatment of conditions, such as neurodegenerative disorders, convulsions or schizophrenia, which require the administration of an NMDA and/or AMPA antagonist.
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申请公布号 |
US5268378(A) |
申请公布日期 |
1993.12.07 |
申请号 |
US19920825442 |
申请日期 |
1992.01.22 |
申请人 |
MERCK SHARP & DOHME, LIMITED |
发明人 |
BAKER, RAYMOND;LEESON, PAUL D.;ROWLEY, MICHAEL;SEVENSON, GRAEME I. |
分类号 |
C07D215/22;C07D215/56;C07D401/04;C07D401/06;C07D401/12;C07D405/04;C07D405/06;C07D409/04;C07D409/06;C07D409/12;C07D413/04;(IPC1-7):C07D215/58 |
主分类号 |
C07D215/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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