PLATELET DERIVED GROWTH FACTOR ANTAGONISTS

摘要

The invention describes antagonists for PDGF. The antagonists contain amino acids, and may be monomers or dimers. Especially preferred are dimers which bind the PDGF receptors, but prevent dimerization of the bound receptors. Dimerization is necessary for PDGF effect, hence the antagonistic effect. Also described are nucleic acid sequences for making the antagonists, as well as cell lines transfected with the material. The figure sets forth amino acid sequences for peptides eluted from PDGF-A HPLC experiments.