| 摘要 |
<p>Novel compounds of formula (I) in which R?1 and R2¿ are hydrogen, C¿1?-C4 alkyl or are linked to form C3-C7 cycloalkyl and R?3, R4 and R5¿ are the same or different and are hydrogen, C¿1?-C4 alkyl, hydroxy, OR?6, SR6¿, halogen, NR7R8, NO2, CN, CONR7R8 or CO¿2R?9 wherein R6 is C1-C4 alkyl or C7-C10 aralkyl and R?7, R8 and R9¿ are the same or different and are hydrogen, C¿1?-C4 alkyl or C7-C10 aralyl or R?7 and R8¿ together with the nitrogen atom to which they are bound form 5 or 6 membered azacyloalkyl or oxazacyloalkyl; Arg is arginine [NH-CH(CH¿2?CH2CH2NH-C(=NH)-NH2)-CO]; X is methine CH or nitrogen; n is an integer from 0 to 7; L is a peptide linker, and H is the carboxy terminal end of hirudin, and salts thereof, are provided. The novel compounds are useful for the medical treatment or prevention of thrombosis or diseases caused by thrombosis or can be used for the determination of thrombin in blood as diagnostic reagents.</p> |
