| 摘要 |
The present invention is directed to a two-step method for incorporating a partially soluble compound into a polymer matrix. The method of the invention comprises the steps of: (1) mixing a first portion of a partially soluble compound in its soluble phase into a polymer at a concentration near or equal to the compound's equilibrium solubility in the polymer to give a single homogeneous phase, followed by (2) mixing a second portion of the partially soluble compound in its solid phase into the polymer in a manner that the compound does not dissolve in the polymer but is dispersed throughout the polymer and the size or size distribution of the particles is controlled. The invention is further directed to compound/polymer compositions prepared by the above process, to delivery devices comprised of such compositions, and to a method of delivering to an environment of use a partially soluble active agent from a polymeric matrix, which method comprises placing an appropriately sized and shaped delivery device of the invention in the environment of use. |
