| 摘要 |
<p>Peptides of the formula Z-P-A-B-C-E-F-K-(D) Q-G-M-F'-I (I), in which Z is Fmoc, dibenzylacethyl group, cyclohexycarbonyl group, N,N-dibenzylglycyl group, 2-(4-isobuthylphenyl)propionyl group, 2R-(terc-buthylsulphonylmethyl)-3-(1-naphtyl)-propionyl group, indole-3-yl-acethyl group, 4-benzoylbenzoyl group, 1,8-naphtalimidoacethyl group, 7-teophylinacethyl group or N-benzoyl group, P is a direct linkage, Aoc, epsilon-aminocyclohexylcarbonyl group, 4-aminomethyl-cyclohexylcarbonyl group or Oic and A is (D)- or (L)-Arg, (D)- or (L)-Lys or linkage, B is Arg; C is Pro-Hyp-Gly; E is Thia; F is Ser; K is a direct linkage; Q is Tic; M is a direct linkage; G is cis-endo-, cis-exo, trans-octahyroindole-2-carboxyl acid; F'is Arg and I is OH or their physiologically acceptable salts, method for their preparation, pharmaceutical composition comprising them and their therapeutical use.</p> |
