| 摘要 |
<p>A variant of a naturally-occurring cytokine having a Phe-Leu or Tyr-Leu sequence in a helical domain and a negatively charged amino acid within two amino acids immediately upstream or downstream from said Phe-Leu or Tyr-Leu sequence, said variant having an increased affinity for the receptor of said naturally-occurring cytokine by virtue of a neutral or basic amino acid having been substituted for a said negatively charged amino acid.</p> |
