发明名称 |
SYNTHETIC, STABILIZED, THREE-DIMENSION POLYPEPTIDES |
摘要 |
Methods for synthesizing three-dimensional stabilized peptides which mimic the three-dimensional configuration of the active site of a natural, biologically active protein are carried out by (1) noting the three-dimensional configuration of the active site of a known biologically active protein, (2) noting the amino acid sequence and the hydrogen bonds existing between amino acids which hydrogen bonds are capable of maintaining the three-dimensional configuration of the active site and (3) producing a synthetic three-dimensional peptide to mimic the structure of the active site. The synthetic peptide is synthesized so as to have the same or a similar amino acid sequence to the amino acid sequence of the active site of the biologically active polypeptide but with the stabilizing hydrogen bonds being replaced by a bridging divalent radical selected from the group consisting of -(N)-C(CH3)=N(H<+>)-CH2-(N)-; -(N)-C(CH3)=N(H<+>)-CH2-CH2-(N)-; and -(N)-N=CH-CH2-CH2-CH2-(C)-. |
申请公布号 |
WO9321206(A1) |
申请公布日期 |
1993.10.28 |
申请号 |
WO1993US03032 |
申请日期 |
1993.03.31 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
SATTERTHWAIT, ARNOLD, C., JR.;ARRHENIUS, THOMAS;CHIANG, LIN-CHANG;CABEZA, EDELMINA |
分类号 |
A61K39/00;C07K1/107;C07K7/02;C07K14/16;C07K14/445;C07K14/485;G01N33/68;(IPC1-7):C07K1/00;C07K7/54;C07K15/00;A61K37/02;C12N15/00;A61K39/395;G01N33/53 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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