摘要 |
A compound of formula (I), or a pharmaceutically acceptable salt thereof, wherei n R is phenyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, furyl or thienyl, all of which may be optionally substit ued by halo, C1-C4 alkyl, C1-C4 alkoxy or a group of the formula: -X-R2; R1 is H, C1-C6 alkyl, C3-C7 cycloalkyl, C5-C7 cycloalkenyl, C3-C6 alkenyl or C3-C6 alkynyl, said alkyl group being optionally substituted by C3-C7 cycloalkyl, C3-C7 cycloalkyloxy, OH, C1-C6 alkoxy, CONR3R4, SO2NR3R4, COR5, SOR5, SO2R5, CO2R6, aryl, aryloxy, aryl(C1-C6)alkoxy or heteroaryl, said a lkenyl group being optionally substituted by aryl and said cycloalkyl group being optionally substituted by OH; the cycloa lkyl and cycloalkenyl groups of the foregoing groups being optionally linked to the N-atom by a C1-C2 alkylene moiet y; R2 is COR7, CO2R7, SOR7, SO2R7, CONR3R4, SO2NR3R4, NHCOR7, NHCONR3R4, NHSO2R7, NHSO2NR3R4, OH or CN; R3 and R4 a re either each independently selected from H, C3-C7 cycloalkyl and C1-C6 alkyl, said alkyl grou p being optionally substituted by C3-C7 cycloalkyl or aryl, or R3 and R4 taken together represent C3-C6 alkylene optiona lly interrupted by O, S(O)n, NH or N(C1-C6 alkyl); R5 is C1-C6 alkyl, C3-C7 cycloalkyl, C3-C7 cycloalkyl(C1-C6)alkylene, ar yl(C1-C6)alkylene or aryl; R6 is C1-C6 alkyl, C3-C7 cycloalkyl or aryl(C1-C6)alkylene; R7 is C1-C6 alkyl; X is a direct link o r C1-C7 alkylene; m is 1 or 2; and n is 0, 1 or 2; are selective 5-HT1-like receptor agonists useful in the treatment of migrain e, cluster headache, chronic paroxysmal hemicrania and headache associated with vascular disorders.
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