发明名称 |
Expression of antigenic Epstein-Barr virus polypeptides in bacteria and their use in diagnostics |
摘要 |
Bacterially synthesized polypeptides that are recognized by antibodies produced in EBV-infected humans are disclosed. Plasmids containing DNA sequences encoding portions of the EBNA and EBEA-D antigens are also disclosed, as are methods for expressing these DNA sequences in bacteria. The DNA sequence encoding the EBNA-1-related fusion polypeptide is found in a Bam H1 K-restriction fragment, while that encoding the EBEA-D-related fusion polypeptide is found in a Bam H1 M-restriction fragment.
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申请公布号 |
US5256768(A) |
申请公布日期 |
1993.10.26 |
申请号 |
US19900578480 |
申请日期 |
1990.09.05 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
MILMAN, GREGORY |
分类号 |
C07K14/05;(IPC1-7):A61K39/245;C07K15/04;C07K13/00 |
主分类号 |
C07K14/05 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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