| 摘要 |
PCT No. PCT/GB94/01940 Sec. 371 Date Feb. 29, 1996 Sec. 102(e) Date Feb. 29, 1996 PCT Filed Sep. 7, 1994 PCT Pub. No. WO95/07253 PCT Pub. Date Mar. 16, 1995This application relates to 3-substituted and 4-substituted cis-diols. Specifically, there are provided 3-substituted diols of formula (II) and 4-substituted cis-diols having (1S, 2R) and (1R, 2S) absolute configurations of formulae (III) and (IV). Also provided are processes For making such 3- and 4-substituted cis-diols using a reductive fission reaction. The compounds described herein are useful as synthons for the preparation of various compounds including therapeutics, agricultural, polymers and other classes of compounds. In formulae (II, III and IV), R is halogen, CN, aryl alkyl, alkenyl alkynyl O-alkyl, CF3 or NO2. |
