| 摘要 |
<p>Substituted phenylcarbamates and ureas of formula (I) wherein R1 represents a hydrogen or a halogen atom, or a C¿1-6?alkyl, C1-6alkoxy or hydroxy group; R?2¿ represents an oxadiazole or thiadiazole ring substituted by a group selected from C¿1-6?alkyl, C3-7cycloalkyl, -CH2C2-5alkenyl, -CH2C2-5alkynyl, phenyl or benzyl; X represents NH or an oxygen atom; m represents 0, 1 or 2; R?3¿ represents C¿1-6?alkyl, benzyl, -(CH2)nR?4¿ or (a); R4 represents a group selected from cyano, hydroxyl, C¿1-6?alkoxy, phenoxy, C(0)C1-6alkyl, C(0)C6H5, -CONR?6R7, -NR6COR7, -SO¿2NR?6R7 or -NR6SO¿2R7 (wherein each of R?6 and R7¿ independently represent a hydrogen atom, a C¿1-6?alkyl or phenyl group); n represents 2 or 3; R?5¿ represents COR8 or SO¿2R?8 (wherein R8 represents a hydrogen atom, a C¿1-6?alkyl or phenyl group); and quaternary ammonium derivatives, piperidine N-oxides and pharmaceutically acceptable salts and solvates thereof; which compounds are potent and specific antagonists of 5-hydroxytryptamine (5HT; seretonin).</p> |
