| 摘要 |
PURPOSE:To obtain an accelerator for producing the nerve growth factor (NGF) containing malformins known as compounds having action to cause heteromorphism in plants. CONSTITUTION:The accelerator includes at least one from malformin A1 of formula I, malformin A2 of formula II, malformin A3 of formula III and malformin A4 of formula IV as an active ingredient. Said NGF production accelerator increases the capacity of NGF production in the target tissue, thus being efficacious in prophylaxis and treatment for nervous diseases caused by denaturation and deciduation of nerve cells such as Alzheimer's dementia and in restoration of damaged peripheral nerves. The compounds can be produced through fermentation, for example, by culturing Aspergillus sp. H143 (FERM-P-12673) and isolating it from the supernatant. |
