发明名称 |
Heteroarylnaphthalene hydroxy acids as inhibitors of leukotriene biosynthesis |
摘要 |
Compounds having the formula I: <IMAGE> I are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.
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申请公布号 |
US5252599(A) |
申请公布日期 |
1993.10.12 |
申请号 |
US19920936810 |
申请日期 |
1992.08.27 |
申请人 |
MERCK FROSST CANADA, INC. |
发明人 |
GIRARD, YVES;FORTIN, REJEAN;DELORME, DANIEL;DUBE, DANIEL;HAMEL, PIERRE;DUCHARME, YVES;GILLARD, JOHN W. |
分类号 |
C07D405/14;C07D407/12;C07D409/12;C07D409/14;C07D493/08;(IPC1-7):A61K31/35;C07D309/10 |
主分类号 |
C07D405/14 |
代理机构 |
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代理人 |
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