发明名称 Process for the preparation of beta-phenylisoserine and analogues thereof
摘要 PCT No. PCT/FR93/00224 Sec. 371 Date Sep. 26, 1994 Sec. 102(e) Date Sep. 26, 1994 PCT Filed Mar. 8, 1993 PCT Pub. No. WO93/17997 PCT Pub. Date Sep. 16, 1993This invention relates to a method for preparing beta -phenylisoserine and analogues thereof having general formula (I) <IMAGE> (I) from an aromatic aldehyde and an alpha -methylarylamine-S, and through a lactam of general formula (II) as described herein. The acids of general formula (I) (R=H) may be used to prepare taxane derivatives having remarkable antitumoral and antileukaemic activity.
申请公布号 ZA9301677(B) 申请公布日期 1993.10.06
申请号 ZA19930001677 申请日期 1993.03.09
申请人 RHONE-POULENC RORER S.A. 发明人 JEAN-DOMINIQUE BOURZAT;ALAIN COMMERCON
分类号 C07C227/18;C07C227/22;C07C229/34;C07D205/08;C07D305/14 主分类号 C07C227/18
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