| 摘要 |
There are disclosed compounds of the formula <IMAGE> wherein R1 is hydrogen or lower alkyl; R2 is C3-7 alkyl or C3-7 cycloalkyl; R3 is hydrogen, lower alkyl, carboxyloweralkyl, lower alkoxycarbonyl, lower alkoxycarbonyl loweralkyl, aryl or aralkyl; R4 is hydrogen, C1-8alkyl, <IMAGE> B is a bond, NH or O; Y is O or S; A is a bond or -C=C-; n is 0-5 R5 may be hydrogen when B is NH, or R5 is lower alkyl, C3-8 cycloalkyl, aryl, substituted aryl, aralkyl, substituted aralkyl, aralkenyl, aralkenylalkyl, <IMAGE> -(CH2)nNR1R1 or -(CH2)nhet, where het is a 5- or 6-membered, saturated or unsaturated, nitrogen- or sulfur- or oxygen-containing monoheterocycle, optionally substituted with lower alkyl or oxo; R6 is hydrogen or halo; the dotted line represents an optional double bond; and the pharmacologically acceptable salts thereof, which by virtue of their ability to selectively inhibit PDE IV, are bronchodilatory and anti-inflammatory and so are useful in the treatment of acute and chronic bronchial asthma and associated pathologies.
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