摘要 |
Compounds are described of formula (I), wherein R<1> represents a hydroxyl group or a group selected from -OCOCH=<E>CHCH(CH3)(CH2)3CH3, -OCOCH=<E>CHC(CH3)=<E>CHCH(CH3)CH2CH3 or -OCO-X-CH2CH(CH3)CH2CH3 [where X is -CH=<E>CHCH(CH3)-, -CH2CH(OH)CH(CH3)-, -CH=<E>CHC(OH)(CH3)-, -CH2CH(OH)CH2- or -CH2CH2CH(CH3)-]; R<2> represents a hydroxyl group; R<3> represents a group selected from (1) (where R<7> is a hydrogen atom or an acetyl group), -C(CH3)=<E>CHCH(CH2R<8>)CH2Ph (where R<8> is a hydrogen or a hydroxyl group), -C(CH2OH)=<Z>CHCH(CH3)CH2Ph, -C(=CH2)CH(OH)CH(CH2OH)CH2Ph, -C(=CH2)CH(NHCOCH3)CH(CH3)CH2Ph, -C(CH2NHCOCH3)=<E>CHCH(CH3)CH2Ph and (2); R<4> and R<5> may each independently represent a hydrogen atom or a methyl group; R<6> represents a tetrazole ring linked via the ring carbon atom to the rest of the molecule and optionally substituted at one of the ring nitrogen atoms by a C1-4alkyl group; and salts thereof. These compounds inhibit the enzyme squalene synthase and/or are intermediates for the preparation of compounds which inhibit the enzyme squalene synthase. Compounds of the inventions may be formulated for use in a variety of conditions where a lowering of the level of blood plasma cholesterol in animals would be beneficial and for use in combating fungal infections in animals. |