发明名称 |
Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression |
摘要 |
PCT No. PCT/US91/04681 Sec. 371 Date Feb. 18, 1993 Sec. 102(e) Date Feb. 18, 1993 PCT Filed Jul. 1, 1991 PCT Pub. No. WO92/02258 PCT Pub. Date Feb. 20, 1992Oligonucleotide analogs are provided having improved nuclease resistance. Modifications of selected nucleotides through substitutions on the pyrimidine ring are disclosed. Certain preferred embodiments comprise the inclusion of said modified nucleotides at a plurality of sites, especially at the 3' end of a selected oligonucleotide analog. |
申请公布号 |
AU641565(B2) |
申请公布日期 |
1993.09.23 |
申请号 |
AU19910087205 |
申请日期 |
1991.07.01 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
PHILIP DAN COOK;YOGESH SHANTILAL SANGHVI |
分类号 |
A61K48/00;C07H19/10;C07H19/12;C07H21/00;C12N15/09;(IPC1-7):A61K48/00;A61K31/70 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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