ENKASTINE: NEUE GLYCOPEPTIDE MIT ENKEPHALINASE-HEMMENDER WIRKUNG, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS PHARMAZEUTISCHE PRAEPARATE.

摘要

Glycopeptides of formula Sacch-A-B-R (I) and their physiologically acceptable salts are new. Sacch = monosaccharide residue, opt. having OH gps. partly or completely substd.; A = residue of a neutral L- or D-amino acid, but if B is omitted, it must be D-form; B is absent or is the residue of a neutral L- or D-amino acid, or of an opt. omega-substd. bifunctional acidic or basic L- or D-amino acid; R = OH, 1-8C alkoxy, amino (opt. substd. by 1 or 2 same or different 1-8C alkyl, 5-8C cycloalkyl, 5-8C heteroalkyl or 5-8C heteroaryl) or some other acid deriv. The cpds. N-(1-deoxy-beta-D-fructopyranos-1-yl)- Gly-(Gly or Ser)-OH are also claimed.