| 摘要 |
This invention relates to proteins encoded by vaccinia virus and which function to interfere with the host's immune system. In particular, the invention provides for use of the nucleotide sequence designated herein as B15R or of a nucleotide sequence coding for an allele of, or functionally equivalent fragment, derivative or variant of the polypeptide encoded by the B15R nucleotide sequence in a process relating to the manufacture of a medicament for the treatment of a condition in which interleukin-1 beta is involved in the mediation of one or more symptoms associated with the condition. The invention also provides an anti-fever medicament which comprises a polypeptide which is encoded by the B15R gene product or an allele of, or functionally equivalent fragment, derivative or variant of that product. |
