| 发明名称 |
Camptothecin analogs as potent inhibitors of topoisomerase I |
| 摘要 |
A method for synthesizing camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase.
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| 申请公布号 |
US5244903(A) |
申请公布日期 |
1993.09.14 |
| 申请号 |
US19900600825 |
申请日期 |
1990.10.22 |
| 申请人 |
RESEARCH TRIANGLE INSTITUTE |
发明人 |
WALL, MONROE E.;WANI, MANSUKH C.;NICHOLAS, ALLAN W.;MANIKUMAR, GOVINDARAJAN |
| 分类号 |
A61K31/47;A61K;A61K31/44;A61P35/00;A61P43/00;C07D;C07D471/04;C07D491/14;C07D491/20;C07D491/22;C12N9/00;C12N9/90;C12N9/99 |
主分类号 |
A61K31/47 |
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