Method for the preparation of vicinal aminoalcohols and optically active O-protected derivatives thereof.

摘要

The present invention is concerned with the preparation of N-substituted vicinal aminoalcohol derivatives from the corresponding hydroxyl-protected cyanohydrin derivatives by successive partial reduction, transimination using a primary amine, reduction of the resulting imine and optional removal of the hydroxyl-protecting group. The products are obtained either as a racemate or in an optically pure form, depending upon the stereochemical composition of the cyanohydrin derivatives.
The present invention is also concerned with optically active intermediate products of this reaction having the general formula 9