发明名称 USE OF AGGREGATED PROTEINS TO PROLONG RETENTION TIME OF A THERAPEUTIC AGENT ADJACENT A TARGETED SITE SUCH AS A TUMOR
摘要 A method of prolonging the amount of time it takes for the system of a living being to remove a therapeutically effective agent from a targeted site in the living being, such as in a tumor or tumor bearing region. The method comprises the steps of selecting particles of an aggregated protein, such as macro aggregated albumin. The protein particles are provided to the targeted site in the living being. A therapeutically effective agent, such as colloidal radioactive phosphorous, is then provided to the targeted site in the living being. In an alternative embodiment, the therapeutically effective agent may be mixed with a second aliquot of the aggregated protein particles to produce a mixture thereof. The mixture is then provided to the targeted site in the living being. The aggregated protein may be any suitable protein such as albumin, gamma globulin or peptides having a particle size of approximately 10 to 70 micrometers. In a preferred embodiment, the targeted site is the tumor itself.
申请公布号 WO9316735(A1) 申请公布日期 1993.09.02
申请号 WO1993US01848 申请日期 1993.02.18
申请人 ORDER, STANLEY, E. 发明人 ORDER, STANLEY, E.
分类号 A61K9/16;A61K47/48;A61K51/12 主分类号 A61K9/16
代理机构 代理人
主权项
地址