发明名称 |
PROCCESS FOR PRODUCING THROMBIN INHIBITORS BASED ON AMINO ACID SEQUENCE OF HIRUDINE AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME |
摘要 |
<p>A thrombin inhibitor comprising a first bulky hydrophobic portion interacting with the catalytic site of thrombin responsible for proteolysis and a second portion at least maintaining the hydrophobic and acidic character of amino acids 55 to 60 of native hirudin at the C-terminal non-catalytic region of N-acetyl-hirudin45-65. Between the first and second portions is a divalent linker moiety having a chain length of at least 10 carbon atomes. Preferably, the bulky hydrophobic portion comprises at least one amino acid of D-configuration. The compounds are useful in the treatment of thrombotic disorders.</p> |
申请公布号 |
HUT63440(A) |
申请公布日期 |
1993.08.30 |
申请号 |
HU19920003968 |
申请日期 |
1991.06.14 |
申请人 |
NATIONAL RESEARCH COUNCIL OF CANADA,CA |
发明人 |
DIMAIO,JOHN,CA;NI,FENG,CA;KONISHI,YASUO,CA |
分类号 |
A61K31/195;A61K38/00;A61K38/55;A61P7/02;C07C69/602;C07C279/12;C07C303/40;C07C311/18;C07C311/19;C07C311/64;C07K7/02;C07K7/06;C07K7/08;C07K14/81;C07K14/815;C12N9/99;(IPC1-7):C07K7/10;A61K37/64 |
主分类号 |
A61K31/195 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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