| 摘要 |
In the synthesis of simvastatin by direct methylation of lovastatin, selecti ve hydrolysis of residual lovastatin, lovastatin acid or a salt thereof by treatment with a bacterium or fungus capable of hydrolyzing the 2-methyl-butyryloxy side chain or a mutant of such microbe or a cell-free extract derived therefrom, or a hydrolase derived therefrom yields 7-[1',2',6',7',8',8a'(R)-hexahydro- 2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)naphthyl]-3(R),5(R)-dihydroxy- heptanoic acid, the triol acid, or triol salt which can be easily separated from simvastatin, either before or after lactonization to t he lactone form. This process produces simvastatin of high yield and purity.
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