PROCESS FOR THE PURIFICATION OF A 3-CEPHEM-4-CARBOXYLIC ACIDDERIVATIVE

摘要

2124322 9316084 PCTABS00025 The invention relates to a new process for the depletion of 7-amino-3-¢(E)-1-propen-1-y1!-3-cephem-4-carboxylic acid in mixtures of 7-amino-3-¢(Z)-1-propen-1-y1!-3-cephem-4-carboxylic acid and 7-amino-3-¢(E)-1-propen-1-y1!-3-cephem-4-carboxylic acid, by means of the crystalline hydrochloride or a metal or amine salt of 7-amino-3-¢(Z/E)-1-propen-1-y1!-3-cephem-4-carboxylic acid or by adsorption chromatography.