| 摘要 |
7616P/5485A 17716Y TITLE OF THE INVENTION HUMORAL HYPERCALCEMIC FACTOR ANTAGONISTS The present invention relates to the use of peptide analogues as inhibitors of their respective naturally occurring peptides. The structure of the peptide analogues is exemplified by an internal region of the N-terminus of humoral hypercalcemic factor hHCF, and truncations thereof: hHCF(14-34)NH2, hHCF(13-34)NH2, hHCF(12-34)NH2, hHCE(11-34)NH2, hHCF(10-34)NH2, hHCF(9-34)NH2, hHCF(8-34)NH2, hHCF(7-34)NH2, hHCF(6-34)NH2, hHCF(5-34)NH2, hHCF(4-34)NH2, hHCF(3-34)NH2, and these peptides containing various amino acid substitutions. |
