METHOD OF SYNTHESIS OF DERIVATIVES OF 2-METHYL-4,5-DIHYDROXYBENZOIC ACID OR THEIR PHARMACOLOGICALLY ACCEPTABLE SALTS

摘要

In accordance with the present invention, disclosed herein are compounds of the formula wherein R is hydrogen, straight or branched loweralkyl, cycloalkyl, amino, loweralkoxy or acylamino, and R1 is straight or branched loweralkyl, amino, cyclohexyl, morpholino, piperidino, tetrahydrofuranyl, dihydrofuranyl, furanyl, tetrahydropyranyl, dioxolanyl, 2,2-dimethyl dioxolanyl, dioxanyl, pyrrolidinyl, tetrahydrooxazolyl, and dihydrooxazolyl, R2 is hydrogen or -COR3 wherein R3 is straight or branched loweralkyl, provided, however, when R1 is loweralkyl or cyclohexyl, R2 is not hydrogen, and pharmaceutically acceptable salts thereof. The compounds are useful in the treatment of glaucoma.