| 摘要 |
This invention relates to alkylated sulfonium alkylene derivatives of certain 2H-1-benzopyrans, of the formula <CHEM> the (R) and (S) enantiomers and racemic mixtures thereof, and the pharmaceutically acceptable salts thereof wherein Q is S<(+)>R1R2.X<(-)>, X is a halide or OS (O)2R3, with R3 being H, C1-6 alkyl, CF3, aryl or aralkyl, R1 is C1-6 lower alkyl, phenyl, benzyl or phenethyl, R2 is C1-6 alkyl, and R1 and R2 are a C4- to C6 alkylene which, togehter with the sulfur atom to which they are attached, form a 5-, 6- or 7-membered ring, R5 is H or C1-6 alkyl, R6 is H or -C(O)R, R beihg H or C1-9 alkyl, R7 is H or C1-6 alkyl, R8 is H or C1-6 alkyl and n is an integer of 1 to 6, to the intermediates and processes useful for their preparation, to their free-radical scavenger and cardioprotective properties and to their and-use application as therapeutic agents. |
