发明名称 |
Detoxified lps-cholera toxin conjugate vaccine for prevention of cholera |
摘要 |
A vaccine formulation comprising conjugates of detoxified LPS with proteins including cholera toxin (CT) is disclosed. Treatment with hydrazine (DeA-LPS) reduces the endotoxic properties of the LPS to clinically acceptable levels and results in a larger and more antigenic molecule than the saccharide produced by acid hydrolysis. The conjugates utilizing the cholera toxin of V. cholerae are disclosed which have low levels of pyrogen, no toxic activity upon Chinese hamster overay cells and elicit booster responses of vibriocidal and CT antibodies when injected subcutaneously as saline solutions into mice. The conjugates produced as a cholera vaccine induce the same antibodies as parenterally injected cellular vaccines but have improved safety and immunologic properties. |
申请公布号 |
AU3469693(A) |
申请公布日期 |
1993.08.03 |
申请号 |
AU19930034696 |
申请日期 |
1993.01.14 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED B |
发明人 |
SHOUSUN C SZU;JOHN B ROBBINS;RAJESH K GUPTA |
分类号 |
A61K39/00;A61K39/10;A61K39/106;A61K47/48;A61P31/04 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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