HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE

摘要

2127251 9314090 PCTABS00024 The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds of formula (I) wherein X and Z independently are oxygen or sulfur; and G is independently selected from the group of azacyclic or azabicyclic ring systems consisting of a and b wherein the oxadiazole or thiadiazole ring can be attached at any position. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.