| 摘要 |
11-hydroxysteroids of formula (I), their quat. ammonium salts when R1 and/or R2=haloalkyl, and the intermediate cpds. (II), (IV), (V), (VII), (VIII) and (IX) are new, where Q=R2 in (III); H in (N); M in (V); Q1=H in (VII); R2 in (VIII). R1=1-10C alkyl (opt. substd. by 1 or more halo); 2-10C mono-or poly-hydroxy-alkyl; CH2COOR6; CH2CONR7R8; -CHR9. Y-(alkyl); (a), (b) or opt. substd. phenyl or benzyl; R6=opt. substd. 1-10C alkyl, 3-8C cycloalkyl or cycloalkenyl, 2-10C alkenyl (the substits. being halo; lower alkylthio, alkoxy, alkylsulphinyl or alkylsulphonyl; -NHCO. (1-10C alkyl) or -OCO. (1-10C alkyl)); or opt. substd. phenyl or benzyl (substits. being lower alkyl or alkoxy, halo, CONH2 (opt. substd. by 1 or 2 lower alkyl), lower alkoxycarbonyl, lower alkanoyloxy, lower haloalkyl, mono-or di-lower alkylamino, lower alkylthio, alkylsulphinyl or alkylsulphonyl); R7 and R8=H, lower alkyl, 3-8C cycloalkyl, phenyl or benzyl, or together complete a satd. heterocyclic ring; Y=S, SO, SO2 or O; R9=H, lower alkyl or phenyl; alk=3-10C alkylene, at least 3 but no more than 6 are ring atoms; R10=H, lower alkyl, phenyl or halophenyl; R2 as R6; R3=H; alpha or beta OH; alpha or beta Me;=CH2; or alpha or beta OR2; R4=H, F or Cl; R5=H, F, Cl or Me; X=O or S; Z=CO or beta-hydroxymethylene; R13=R3 but not OH; M=equivl of alkali or alkaline earth metal, Tl or NH4; R"3=R'3 but not=CH2.
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