发明名称 |
ICAMS IMMUNOGLOBULIN CONSTANT REGION SOLUBLE FUSION PROTEINS |
摘要 |
Soluble fusion molecules were prepared which contained a CD11a/CD18 specific binding region operatively linked to an immunoglobulin constant region. These molecules particularly include extracellular portions of adhesion molecules such as ICAM-1 and ICAM-2 attached to IgG constant regions. The fusion molecules described are utilized as costimulatory agents for the activation of T cells and in methods for increasing CD4<+> T cell proliferative response and IL-2 induction. |
申请公布号 |
WO9313210(A1) |
申请公布日期 |
1993.07.08 |
申请号 |
WO1992US10964 |
申请日期 |
1992.12.15 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
ARUFFO, ALEJANDRO;DAMLE, NITIN |
分类号 |
C12N15/09;A61K38/00;A61P37/02;C07K14/52;C07K14/54;C07K14/55;C07K14/705;C07K14/725;C07K16/00;C07K19/00;C12P21/02;C12R1/91 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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