A fast acting and adjustable vise is disclosed herein having an elongated base movably supporting a pair of jaws adjustable between opposing holding surfaces for releasably supporting small parts or workpieces. Manually rotatable wheels are operably coupled to each jaw for independent and separate movement along a linear path and a universal mounting device adjustably supports the vise on a supporting surface. In one form, one jaw of the pair includes a finger-operated resilient clamp for selectively and rapidly positioning the clamp to a desired location on the base.