| 摘要 |
<p>A compound of the formula : <CHEM> wherein R<1> is halogen, heterocyclic group which may have one or more suitable substituent(s), aryl which may have one or more suitable substituent(s), -NH-R<5> (in which R<5> is hydrogen, lower alkanoyl or hydroxy(lower)alkyl), -S-R<6> (in which R<6> is lower alkyl, lower alkyl substituted with carboxy and amino, lower alkyl substituted with protected carboxy and protected amino, or pyridyl), -O-R<7> (in which R<7> is hydrogen, hydroxy protective group, lower alkyl, lower alkenyl, ar(lower)alkyl, halo(lower)alkyl, amino(loweralkyl, protected amino(lower)alkyl, or piperazinyl(lower)alkyl which may have lower alkyl), -CONH-R<8> (in which R<8> is cyano, carbamoyl(lower)alkyl, carboxy(lower)alkyl, protected carboxy(lower)alkyl, or lower alkyl substituted with carbamoyl and aryl ), or -Z-R<9> [in which R<9> is hydrogen or lower alkyl, and Z is <CHEM> (wherein is hydroxy, lower alkoxy or amino) or <CHEM> (wherein R<1><1> is carboxy or protected carboxy and R<1><2> is hydrogen; or R<1><1> is halogen and R<1><2> is halogen)], R<2> is aryl which may have one or more suitable substituent(s), R<3> is hydrogen or halogen, R<4> is hydrogen, halogen or lower alkoxy and A is lower alkylene, and a pharmaceutically acceptable salt thereof, processes for the preparation and pharmaceutical compositions comprising them as an active ingredient</p> |
