发明名称 |
PROCESS FOR PRODUCING NEW, FURYL AND THIENYL GROUP-SUBSTITUTED TAXANE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH COMPOUNDS AS ACTIVE INGREDIENT |
摘要 |
<p>A taxane derivative of the formula <CHEM> wherein R<5> is <CHEM> Z is -OT<5>, T<5> is hydrogen, hydroxyl protecting group, or -COT<6>, T<6> is H, C<5>-C1/4 alkyl, C<5>-C1/4 alkenyl, C<5>-C1/4 alkynyl or monocylic aryl, R<7> is benzoyl, substituted benzoyl or C<5>-C1/4 alkoxycarbonyl, Ac is acetyl, and E<5> and E<6> are independently selected from hydrogen and functional groups which increase the water solubility of the taxane derivative are useful as antitumor agents.</p> |
申请公布号 |
HUT62886(A) |
申请公布日期 |
1993.06.28 |
申请号 |
HU19920003017 |
申请日期 |
1992.09.22 |
申请人 |
FLORIDA STATE UNIVERSITY,US |
发明人 |
HOLTON,ROBERT A.,US;BEIDIGER,RONALD J.,US;NADIZADEH,HOSSAIN,US |
分类号 |
A61K31/34;A61K31/341;A61K31/38;A61K31/381;A61P35/00;C07D305/14;C07D407/12;C07D409/12;C07F7/00;C08G67/00;(IPC1-7):C07D407/12;A61K31/335 |
主分类号 |
A61K31/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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