| 摘要 |
This invention concerns compounds of formula (I) wherein E represents hydrogen, C1-C6 alkyl or a group Ar<1>-A<1>-; Ar and Ar<1> when present each represent an aryl group of 6 to 10 carbon atoms or a heteroaryl group of 5 to 10 ring atoms, which are optionally substituted by one or more substituents selected from alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, halogen, haloalkyl of 1 to 6 carbon atoms, haloalkoxy of 1 to 6 carbon atoms, cyano, amino, mono- or di- (C1-C6) alkylamino, hydroxy and nitro; A and A<1> when present are the same or different alkylene groups having one or two carbons linking Ar or Ar<1> to N, each optionally substituted by alkyl of 1 to 6 carbon atoms and/or an optionally substituted Ar group as defined above. B is a straight chain alkylene group of 3 or 4 carbon atoms optionally substituted by alkyl of 1 to 6 carbon atoms, and D represents P(O)(OR<1>)(OR<2>), P(O)(H)(OH) or P(O)(R<3>)(OR<4>) where R<1> and R<2> are independently hydrogen, alkyl of 1 to 6 carbon atoms or alkyl of 7 to 12 carbon atoms; R<3> is -CH(Oalkyl)2 in which the alkyl group contains 1 to 6 carbon atoms and R<4> is alkyl of 1 to 6 carbon atoms or aralkyl of 7 to 12 carbon atoms which compounds are GABA autoreceptor agonists useful as antidepressants and for treating senile dementia. |
