COMPOSITIONS FOR ELICITING CYTOTOXIC T-LYMPHOCYTE RESPONSES AGAINST VIRUSES

摘要

2124691 9310816 PCTABS00022 The present invention provides compositions and methods for the prevention and treatment of viral infections. The identification of distinct classes of peptides for use in both anti-viral vaccines and therapeutic formulations is reported. Peptide formulations are disclosed which enhance the systemic distribution, activity, and longevity of anti-viral cytotoxic T cells, and/or which protect human cells from HIV infection. A novel method for the rapid screening of cytotoxic T lymphocyte- (CTL-) inducing compounds, for use in CTL vaccines and in the preparation of specifically primed CTLs, is also disclosed.