发明名称 |
HYDROXYLETHYLSTARCH (HES) AS PLASMA EXPANDER AND PROCESS FOR PREPARING HES |
摘要 |
A hydroxyethyl starch for use as plasma expander which is obtainable by hydrolytic predegradation of a starch rich in amylopectin, partial hydroxyethylation to a specific substitution degree in the presence of alkali and subsequent hydrolytic degradation to a specific molecular weight, comprises a mean molecular weight of 60,000-600,000 and a substitution degree MS of 0.15-0.5. The ratio of the substitution of C2 to the substitution of C6 of the anhydroglucose units is 8-20 and the substitution degree DS lies in the range from 0.15 to 0.5. A process for the preparation of this hydroxyethyl starch employs 2-chloroethanol as hydroxyethylation agent. The hydroxyethylation is carried out under alkaline conditions at room temperature, the pH value held at a value of about 12 and the temperature held at a value of about 20 DEG C.
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申请公布号 |
US5218108(A) |
申请公布日期 |
1993.06.08 |
申请号 |
US19900533294 |
申请日期 |
1990.06.05 |
申请人 |
FRESENIUS AG |
发明人 |
SOMMERMEYER, KLAUS;CECH, FRANZ;WEIDLER, BURGHARD;HENNING, KLAUS |
分类号 |
A61K31/715;A61P7/08;C08B31/12 |
主分类号 |
A61K31/715 |
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地址 |
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