| 摘要 |
Non-peptidyl compounds characterized generally as heterocyclic acyl aminodiol beta -amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are compounds of the formula <IMAGE> wherein R1 is selected from aryl and aralkyl groups represented by <IMAGE> and wherein R1 may be further selected from heteroaryl and heteroaralkyl represented by <IMAGE> <IMAGE> <IMAGE> <IMAGE> wherein each of T and A is independently selected from N and CH; wherein n is a number selected from zero through five, inclusive; wherein X is selected from oxygen atom, methylamino and NH; wherein each of Y and Z is independently selected from chloro, fluoro, methoxy and dimethylamino; wherein Q is oxygen atom; and wherein each of T and A is independently selected from N and CH; wherein each of R2 and R4 is independently selected from hydrido and methyl; wherein R3 is selected from methyl and ethyl; wherein R5 is cyclohexylmethyl; wherein R6 is hydroxy; wherein R7 is selected from isobutyl and ethyl; wherein each of R8 and R9 is independently selected from hydrido, methyl and isopropyl; or a pharmaceutically-acceptable salt thereof;
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