ANTICORPOS MONOCLONAIS QUIMERICOS E HUMANOS QUE SE LIGAM A EPITOPOS DE RECEPTORES DE FACTOR DE CRESCIMENTO DA EPIDERME, SEUS VECTORES DE EXPRESSAO, PROCESSO DE PREPARACAO E COMPOSICOES FARMACEUTICAS QUE OS CONTEM

摘要

The invention relates to new humanized monoclonal antibodies deriving from murine anti-EGFR antibody 425 comprising an artificial modified consensus sequence at least of the FRs in the variable region of the heavy chain of human immunoglobulins. The invention relates, furthermore, to humanized and chimeric monoclonal antibodies which are binding to epitopes of the epidermal growth factor receptor (EGFR). The invention discloses the amino acid sequences of the responding antigen-binding site for this receptor.