| 摘要 |
<p>A prefilled syringe system is provided for two component pharmaceuticals, which is a combination of a first subassembly consisting of a capped bottomless pharmaceutical vial (2) containing a first component and closed at its botto m end by a piston (32) which can be connected to a plunger (16) and a second subassem- bly (3) consisting of a shell (4) containing a second component and closed b y a fur- ther piston (6) and located in telescopable relationship with the plunger, a cap (18) which can be forced onto the cap (36) of the bottomless vial, and a double ended noodle (320) or a functionally equivalent cannula assembly which is caused t o pierce both pistons as the assemblies are connected by forcing the cap (18) onto the bottomless vial, thus placing the vials in communication. The shell vial (4) is pressed towards the bottomless vial (2) to express its contents into the latter, and the plunger (16) and shell vial {4) are then removed so that the cap (18) an d needle (20) are left connected to the bottomless vial (2) and the plunger (16) may be con- nected to the piston (32) of the bottomless vial to convert it into a syring e. The shell vial may telescope either over or within the plunger. In the first case, the plunger ads to operate the piston of the shell vial during expression of its content s, whereas in the latter case a separate component (8) is required for this purpose.</S DOAB></p> |
