发明名称 |
Solid tumor treatment method and composition |
摘要 |
A liposome composition for localizing an anti-tumor compound to a solid tumor via the bloodstream. The liposomes, which contain the agent in entrapped form, are composed of vesicle-forming lipids and between 1-20 mole percent of a vesicle-forming lipid derivatized with hydrophilic biocompatible polymer, and have sizes in a selected size range between 0.07 and 0.12 microns. After intravenous administration, the liposomes are taken up by the tumor within 24-48 hours, for site-specific release of entrapped compound into the tumor. In one composition for use in treating a solid tumor, the compound is an anthracycline antibiotic drug which is entrapped in the liposomes at a concentration of greater than about 50 mu g agent/ mu mole liposome lipid. The method results in regression of solid colon and breast carcinomas which are refractory to anthracycline antibiotic drugs administered in free form or entrapped in conventional liposomes.
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申请公布号 |
US5213804(A) |
申请公布日期 |
1993.05.25 |
申请号 |
US19910642321 |
申请日期 |
1991.01.15 |
申请人 |
LIPOSOME TECHNOLOGY, INC. |
发明人 |
MARTIN, FRANCIS J.;WOODLE, MARTIN C.;REDEMANN, CARL;YAU-YOUNG, ANNIE |
分类号 |
A61K47/44;A61K;A61K9/127;A61K31/70;A61K38/00;A61K38/11;A61K38/21;A61K38/22;A61K38/27;A61K38/43;A61K38/44;A61K38/46;A61K39/00;A61K39/015;A61K39/21;A61K39/29;A61K47/24;A61K47/34;A61K47/48;A61K49/00;A61P31/04;A61P35/00;C07F9/553 |
主分类号 |
A61K47/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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