发明名称 |
Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds |
摘要 |
The present invention relates to a method of preparing the antiviral compounds 2'-deoxy-5-fluoro-3'thiacytidine (FTC) and various prodrug analogues of FTC from inexpensive precursors with the option of introducing functionality as needed; methods of using these compounds, particularly in the prevention and treatment of AIDS; and the compounds themselves. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds and related compounds. |
申请公布号 |
US5210085(A) |
申请公布日期 |
1993.05.11 |
申请号 |
US19910659760 |
申请日期 |
1991.02.22 |
申请人 |
EMORY UNIVERSITY |
发明人 |
LIOTTA, DENNIS C.;SCHINAZI, RAYMOND F.;CHOI, WOO-BAEG |
分类号 |
A61K31/505;A61K;A61K31/00;A61K31/39;A61K31/513;A61K31/695;A61K31/7064;A61K31/7068;A61P31/12;A61P31/18;C07D;C07D239/02;C07D327/04;C07D405/04;C07D411/04;C07D451/00;C07F7/18;C07H19/06;C07H19/10;C12P19/38;C12P41/00 |
主分类号 |
A61K31/505 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|